Streptozotocin-induced diabetic models in mice and rats

Furman, Brian L. (2021) Streptozotocin-induced diabetic models in mice and rats. Current Protocols, 1. e78. ISSN 2691-1299 (

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Streptozotocin (STZ) is an antibiotic that causes pancreatic islet β‐cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this article are protocols for producing STZ‐induced insulin deficiency and hyperglycemia in mice and rats. Also described are protocols for creating animal models for type 2 diabetes using STZ. These animals are employed for assessing the pathological consequences of diabetes and for screening potential therapies for the treatment of this condition.