Streptozotocin-induced diabetic models in mice and rats

Furman, Brian L. (2021) Streptozotocin-induced diabetic models in mice and rats. Current Protocols, 1. e78. ISSN 2691-1299 (https://doi.org/10.1002/cpz1.78)

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Abstract

Streptozotocin (STZ) is an antibiotic that causes pancreatic islet β‐cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this article are protocols for producing STZ‐induced insulin deficiency and hyperglycemia in mice and rats. Also described are protocols for creating animal models for type 2 diabetes using STZ. These animals are employed for assessing the pathological consequences of diabetes and for screening potential therapies for the treatment of this condition.

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• Item metadata

  Item type:	Article
  ID code:	76333
  Dates:	Date Event 27 April 2021 Published 27 April 2021 Published Online 3 February 2021 Accepted
  Subjects:	Medicine > Pharmacy and materia medica
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
  Depositing user:	Pure Administrator
  Date deposited:	06 May 2021 07:51
  Last modified:	18 Dec 2024 23:48
  URI:	https://strathprints.strath.ac.uk/id/eprint/76333