Vibrational spectroscopic analysis of blood for diagnosis of infections and sepsis : a review of requirements for a rapid diagnostic test
Confield, L. R. and Black, G. P. and Wilson, B. C. and Lowe, D. J. and Theakstone, A. G. and Baker, M. J. (2021) Vibrational spectroscopic analysis of blood for diagnosis of infections and sepsis : a review of requirements for a rapid diagnostic test. Analytical Methods, 13 (2). pp. 157-168. ISSN 1759-9660 (https://doi.org/10.1039/d0ay01991g)
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Abstract
Infections and sepsis represent a growing global burden. There is a widespread clinical need for a rapid, high-throughput and sensitive technique for the diagnosis of infections and detection of invading pathogens and the presence of sepsis. Current diagnostic methods primarily consist of laboratory-based haematology, biochemistry and microbiology that are time consuming, labour- and resource-intensive, and prone to both false positive and false negative results. Current methods are insufficient for the increasing demands on healthcare systems, causing delays in diagnosis and initiation of treatment, due to the intrinsic time delay in sample preparation, measurement, and analysis. Vibrational spectroscopic techniques can overcome these limitations by providing a rapid, label-free and low-cost method for blood analysis, with limited sample preparation required, potentially revolutionising clinical diagnostics by producing actionable results that enable early diagnosis, leading to improved patient outcomes. This review will discuss the challenges associated with the diagnosis of infections and sepsis, primarily within the UK healthcare system. We will consider the clinical potential of spectroscopic point-of-care technologies to enable blood analysis in the primary-care setting.
ORCID iDs
Confield, L. R., Black, G. P., Wilson, B. C., Lowe, D. J., Theakstone, A. G. and Baker, M. J. ORCID: https://orcid.org/0000-0003-2362-8581;-
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Item type: Article ID code: 75413 Dates: DateEvent14 January 2021Published10 November 2020Published Online10 November 2020AcceptedSubjects: Science > Chemistry
MedicineDepartment: Faculty of Engineering > Biomedical Engineering
Faculty of Science > Pure and Applied Chemistry
Professional Services > Technology and Innovation CentreDepositing user: Pure Administrator Date deposited: 15 Feb 2021 15:26 Last modified: 30 Nov 2024 14:16 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/75413