A novel 3D printed hollow microneedle microelectromechanical system for controlled, personalized transdermal drug delivery

Economidou, Sofia N. and Uddin, Md. Jasim and Marques, Manuel J. and Douroumis, Dennis and Sow, Wan Ting and Li, Huaqiong and Reid, Andrew and Windmill, James F.C. and Podoleanu, Adrian (2021) A novel 3D printed hollow microneedle microelectromechanical system for controlled, personalized transdermal drug delivery. Additive Manufacturing, 38. 101815. ISSN 2214-8604

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Abstract

The advancement of drug delivery devices is critical for the individualization of patient treatment and the improvement of healthcare. Here, we introduce the 3DMNMEMS, a novel device that combines 3D printing, microneedles (MNs) and Microelectromechanical Systems (MEMS), allowing versatile and controllable by the user transdermal drug delivery. Hollow MNs were designed and 3D printed using Stereolithography, followed by integrating into a MEMS. By employing advanced imaging techniques, we monitored the distribution of liquid delivered by the device within skin tissue in real time. In vivo testing revealed that the delivery of insulin using the 3DMNMEMS achieved improved glycemic control to diabetic animals compared to subcutaneous injections. These results demonstrated the potential of the 3DMNMEMS as a universal transdermal drug delivery system for personalized care.

ORCID iDs

Reid, Andrew ORCID: https://orcid.org/0000-0003-0511-4640

Windmill, James F.C. ORCID: https://orcid.org/0000-0003-4878-349X

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  Item type:	Article
  ID code:	75028
  Dates:	Date Event 28 February 2021 Published 30 December 2020 Published Online 22 December 2020 Accepted
  Keywords:	microelectromechanical systems, 3D printing, microneedles, optical coherence tomography, in vivo, Electrical engineering. Electronics Nuclear engineering, Electrical and Electronic Engineering, Industrial and Manufacturing Engineering
  Subjects:	Technology > Electrical engineering. Electronics Nuclear engineering
  Department:	Faculty of Engineering > Electronic and Electrical Engineering Strategic Research Themes > Measurement Science and Enabling Technologies Strategic Research Themes > Innovation Entrepreneurship Strategic Research Themes > Health and Wellbeing Strategic Research Themes > Advanced Manufacturing and Materials Technology and Innovation Centre > Sensors and Asset Management
  Depositing user:	Pure Administrator
  Date deposited:	12 Jan 2021 15:25
  Last modified:	07 Jan 2022 05:16
  URI:	https://strathprints.strath.ac.uk/id/eprint/75028