A novel 3D printed hollow microneedle microelectromechanical system for controlled, personalized transdermal drug delivery

Economidou, Sofia N. and Uddin, Md. Jasim and Marques, Manuel J. and Douroumis, Dennis and Sow, Wan Ting and Li, Huaqiong and Reid, Andrew and Windmill, James F.C. and Podoleanu, Adrian (2021) A novel 3D printed hollow microneedle microelectromechanical system for controlled, personalized transdermal drug delivery. Additive Manufacturing, 38. 101815. ISSN 2214-8604

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    Abstract

    The advancement of drug delivery devices is critical for the individualization of patient treatment and the improvement of healthcare. Here, we introduce the 3DMNMEMS, a novel device that combines 3D printing, microneedles (MNs) and Microelectromechanical Systems (MEMS), allowing versatile and controllable by the user transdermal drug delivery. Hollow MNs were designed and 3D printed using Stereolithography, followed by integrating into a MEMS. By employing advanced imaging techniques, we monitored the distribution of liquid delivered by the device within skin tissue in real time. In vivo testing revealed that the delivery of insulin using the 3DMNMEMS achieved improved glycemic control to diabetic animals compared to subcutaneous injections. These results demonstrated the potential of the 3DMNMEMS as a universal transdermal drug delivery system for personalized care.

    Creators(s): Economidou, Sofia N., Uddin, Md. Jasim, Marques, Manuel J., Douroumis, Dennis, Sow, Wan Ting, Li, Huaqiong, Reid, Andrew ORCID logoORCID: https://orcid.org/0000-0003-0511-4640, Windmill, James F.C. ORCID logoORCID: https://orcid.org/0000-0003-4878-349X and Podoleanu, Adrian;
    Item type:Article
    ID code:75028
    Keywords:microelectromechanical systems, 3D printing, microneedles, optical coherence tomography, in vivo, Electrical engineering. Electronics Nuclear engineering, Electrical and Electronic Engineering, Industrial and Manufacturing Engineering
    Subjects:Technology > Electrical engineering. Electronics Nuclear engineering
    Department:Faculty of Engineering > Electronic and Electrical Engineering
    Strategic Research Themes > Measurement Science and Enabling Technologies
    Strategic Research Themes > Innovation Entrepreneurship
    Strategic Research Themes > Health and Wellbeing
    Strategic Research Themes > Advanced Manufacturing and Materials
    Technology and Innovation Centre > Sensors and Asset Management
    Depositing user: Pure Administrator
    Date deposited:12 Jan 2021 15:25
    Last modified:01 Mar 2021 09:26
    URI:https://strathprints.strath.ac.uk/id/eprint/75028
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