Recent advances in therapeutic applications of neutralizing antibodies for virus infections : an overview
Ali, Manasik Gumah and Zhang, Zhening and Gao, Qi and Pan, Mingzhu and Rowan, Edward G. and Zhang, Juan (2020) Recent advances in therapeutic applications of neutralizing antibodies for virus infections : an overview. Immunologic Research, 68 (6). pp. 325-339. ISSN 1559-0755 (https://doi.org/10.1007/s12026-020-09159-z)
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Abstract
Antibodies are considered as an excellent foundation to neutralize pathogens and as highly specific therapeutic agents. Antibodies are generated in response to a vaccine but little use as immunotherapy to combat virus infections. A new generation of broadly cross-reactive and highly potent antibodies has led to a unique chance for them to be used as a medical intervention. Neutralizing antibodies (monoclonal and polyclonal antibodies) are desirable for pharmaceutical products because of their ability to target specific epitopes with their variable domains by precise neutralization mechanisms. The isolation of neutralizing antiviral antibodies has been achieved by Phage displayed antibody libraries, transgenic mice, B cell approaches, and hybridoma technology. Antibody engineering technologies have led to efficacy improvements, to further boost antibody in vivo activities. “Although neutralizing antiviral antibodies have some limitations that hinder their full development as therapeutic agents, the potential for prevention and treatment of infections, including a range of viruses (HIV, Ebola, MERS-COV, CHIKV, SARS-CoV, and SARS-CoV2), are being actively pursued in human clinical trials.”.
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Item type: Article ID code: 74879 Dates: DateEvent31 December 2020Published8 November 2020Published Online21 October 2020AcceptedSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 14 Dec 2020 14:18 Last modified: 11 Nov 2024 12:55 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/74879