Electrochemical monitoring of alcohol in sweat

Biscay, Julien and Findlay, Ewan and Dennany, Lynn (2021) Electrochemical monitoring of alcohol in sweat. Talanta, 224. 121815. ISSN 0039-9140

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    Abstract

    Rapid, periodic monitoring and detection of ethanol (EtOH) after consumption via a non-invasive measurement has been an area of increased research in recent years. Current point-of-care or on-site detection strategies rely on single use sensors which are inadequate for monitoring during a longer period. A low cost, portable and novel approach is developed here for real-time monitoring over several days utilising electrochemical techniques. The sensor shows oxidation of the ethanol in phosphate buffer and artificial sweat using the amperometric response from the application of +0.9 V to the polyaniline modified screen printed electrode using 1 mM EtOH as the averaged amount of EtOH eliminated in sweat after the consumption of one alcoholic beverage. Our enzyme based electrochemical sensor exhibits a qualitative assessment of the presence of EtOH in small volumes (≤40 μL) of 0.1 M sodium bicarbonate and subsequently artificial sweat, with 50 measurements taken daily over 11 days. While quantitative information is not obtained, the sensor system exhibits excellent stability after 3 months’ dried storage in this complex biological matrix in an oxygen free cabinet. This addresses one of the key challenges for enzyme based electrochemical sensors, namely, the ability for real-time monitoring in complex biological matrices. The qualitative response illustrates the potential for this sensor to be exploited by non-experts which suggests the promise for their wider application in next-generation wearable electronics necessary for alcohol monitoring.

    Creators(s): Biscay, Julien, Findlay, Ewan and Dennany, Lynn ORCID logoORCID: https://orcid.org/0000-0002-5481-1066;
    Item type:Article
    ID code:74468
    Keywords:electrochemical sensing, alcohol, biological matrices, reusable device, artificial sweat, Chemistry, Chemistry(all)
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Strategic Research Themes > Health and Wellbeing
    Strategic Research Themes > Measurement Science and Enabling Technologies
    Depositing user: Pure Administrator
    Date deposited:02 Nov 2020 16:42
    Last modified:21 Jan 2021 12:27
    URI:https://strathprints.strath.ac.uk/id/eprint/74468
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