Reducing protein corona formation and enhancing colloidal stability of gold nanoparticles by capping with silica monolayers

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Mosquera, Jesús and García, Isabel and Henriksen-Lacey, Malou and González-Rubio, Guillermo and Liz-Marzán, Luis M. (2019) Reducing protein corona formation and enhancing colloidal stability of gold nanoparticles by capping with silica monolayers. Chemistry of Materials, 31 (1). pp. 57-61. ISSN 0897-4756 (https://doi.org/10.1021/acs.chemmater.8b04647)

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Abstract

A study demonstrated the reducing of protein corona (PC) formation and enhancing colloidal stability of gold nanoparticles (Au NP) by capping with silica monolayers. Au NP surface was needed to achieve silica monolayer formation. In a first attempt to have a high density ligand coverage around NS-1, an excess of 3-mercaptopropyltrimethoxysilane (MPTMS) was directly added to a Au NP hydrosol, but this resulted in immediate aggregation. The resulting trimethoxysilane moiety covering the surface of NS-3 was subsequently hydrolyzed by addition of 5 mM NaOH in a 2:1 methanol/water mixture, yielding a polymeric monolayer.

ORCID iDs

Mosquera, Jesús ORCID logoORCID: https://orcid.org/0000-0001-6878-4567, García, Isabel, Henriksen-Lacey, Malou, González-Rubio, Guillermo and Liz-Marzán, Luis M.;
CORE (COnnecting REpositories)