Tenofovir disoproxil fumarate associated nephrotoxicity : a retrospective cohort study at two referral hospitals in Namibia
Kalemeera, Francis and Godman, Brian and Stergachis, Andy and Rennie, Tim (2021) Tenofovir disoproxil fumarate associated nephrotoxicity : a retrospective cohort study at two referral hospitals in Namibia. Pharmacoepidemiology and Drug Safety, 30 (2). pp. 189-200. ISSN 1053-8569
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Abstract
Introduction: The incidence and risk factors of tenofovir disoproxil fumarate (TDF)-related renal impairment (RI) in Namibia are unknown where TDF-containing ART regimens are used as the first line for HIV. Methodology: A retrospective cohort study among HIV-infected patients at two intermediate hospitals. A decline in estimated glomerular filtration rate (eGFR) was significant if it was ≥25% and included a change to a lower eGFR stage. New-onset RI was defined as an eGFR <50 mL/min/1.73m 2. Results: 10 387 patients were included: 11.4% (n = 1182) experienced the decline in eGFR. Of these, 0.6% (n = 62) migrated to eGFR stages IV and V. The incidence was 4.5 (95% CI: 4.3-4.8) per 100 patient years. RI developed in 400 patients for an incidence rate of 2.4 (95% CI: 2.2-2.6) cases per 100 patient years. Risk factors with effect sizes >2.0, for decline-in-eGFR were baseline eGFR >60 (aHR = 15.6); hyperfiltration (aHR = 5.0); and pregnancy (aHR = 2.4); while for RI, they were hyperfiltration (aHR = 4.1) and pregnancy (aHR = 29). Conclusion: The incidence of decline-in-eGFR was higher than in other sub-SSA countries, but not RI. A high baseline eGFR had the greatest risk for the decline, and hyperfiltration for the RI.
Creators(s): | Kalemeera, Francis, Godman, Brian, Stergachis, Andy and Rennie, Tim; | Item type: | Article |
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ID code: | 73770 |
Keywords: | tenofovir disoproxil fumarate, nephrotoxicity, Namibia, Pharmacy and materia medica, Epidemiology, Pharmacology (medical) |
Subjects: | Medicine > Pharmacy and materia medica |
Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
Depositing user: | Pure Administrator |
Date deposited: | 09 Sep 2020 14:25 |
Last modified: | 21 Jan 2021 12:21 |
Related URLs: | |
URI: | https://strathprints.strath.ac.uk/id/eprint/73770 |
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