Niosome-encapsulated balanocarpol : compound isolation, characterisation, and cytotoxicity evaluation against human breast and ovarian cancer cell lines
Obeid, Mohammad A and Gany, Siti Aisya and Gray, Alexander I and Young, Louise and Igoli, John O and Ferro, Valerie (2020) Niosome-encapsulated balanocarpol : compound isolation, characterisation, and cytotoxicity evaluation against human breast and ovarian cancer cell lines. Nanotechnology, 31 (19). 195101. ISSN 0957-4484 (https://doi.org/10.1088/1361-6528/ab6d9c)
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Abstract
Natural products have been successfully used to treat various ailments since ancient times and currently several anticancer agents based on natural products are used as the main therapy to treat cancer patients, or as a complimentary treatment to chemotherapy or radiation. Balanocarpol, which is a promising natural product that has been isolated from Hopea dryobalanoides, has been studied as a potential anticancer agent but its application is limited due to its high toxicity, low water solubility, and poor bioavailability. Therefore, the aim of this study is to improve the characteristics of balanocarpol and increase its anticancer activity through its encapsulation in a bilayer structure of a lipid-based nanoparticle drug delivery system where the application of nanotechnology can help improve the limitations of balanocarpol. The compound was first extracted and isolated from H. dryobalanoides. Niosome nanoparticles composed of Span 80 (SP80) and cholesterol were formulated through an innovative microfluidic mixing method for the encapsulation and delivery of balanocarpol. The prepared particles were spherical, small, and uniform with an average particles size and polydispersity index ~175 nm and 0.088, respectively. The encapsulation of balanocarpol into the SP80 niosomes resulted in an encapsulation efficiency of ~40%. The niosomes formulation loaded with balanocarpol showed a superior anticancer effect over the free compound when tested in vitro on human ovarian carcinoma (A2780) and human breast carcinoma (ZR-75-1). This is the first study to report the use of SP80 niosomes for the successful encapsulation and delivery of balanocarpol into cancer cells.
ORCID iDs
Obeid, Mohammad A, Gany, Siti Aisya, Gray, Alexander I, Young, Louise, Igoli, John O and Ferro, Valerie ORCID: https://orcid.org/0000-0003-1967-3603;-
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Item type: Article ID code: 73329 Dates: DateEvent20 February 2020Published20 February 2020Published Online20 January 2020AcceptedSubjects: Medicine > Therapeutics. Pharmacology
Science > Physics > Solid state physics. NanoscienceDepartment: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 23 Jul 2020 14:08 Last modified: 23 Oct 2024 00:31 URI: https://strathprints.strath.ac.uk/id/eprint/73329