Patient-centred pharmaceutical design to improve acceptability of medicines : similarities and differences in paediatric and geriatric populations

Liu, Fang and Ranmal, Sejal and Batchelor, Hannah K. and Orlu-Gul, Mine and Ernest, Terry B. and Thomas, Iwan W. and Flanagan, Talia and Tuleu, Catherine (2014) Patient-centred pharmaceutical design to improve acceptability of medicines : similarities and differences in paediatric and geriatric populations. Drugs, 74 (16). pp. 1871-1889. ISSN 0012-6667 (https://doi.org/10.1007/s40265-014-0297-2)

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Abstract

Patient acceptability of a medicinal product is a key aspect in the development and prescribing of medicines. Children and older adults differ in many aspects from the other age subsets of population and require particular considerations in medication acceptability. This review highlights the similarities and differences in these two age groups in relation to factors affecting acceptability of medicines. New and conventional formulations of medicines are considered regarding their appropriateness for use in children and older people. Aspects of a formulation that impact acceptability in these patient groups are discussed, including, for example, taste/smell/viscosity of a liquid and size/shape of a tablet. A better understanding of the acceptability of existing formulations highlights opportunities for the development of new and more acceptable medicines and facilitates safe and effective prescribing for the young and older populations.

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