Investigating the influence of a powder compact's geometry on its pore structure and optical properties using terahertz spectroscopy

Bawuah, P. and Dong, R. and Al-Sharabi, M. and Markl, D. and Zeitler, J. A.; (2019) Investigating the influence of a powder compact's geometry on its pore structure and optical properties using terahertz spectroscopy. In: IRMMW-THz 2019 - 44th International Conference on Infrared, Millimeter, and Terahertz Waves. International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz . IEEE, FRA. ISBN 9781538682852 (https://doi.org/10.1109/IRMMW-THz.2019.8874415)

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Abstract

In this study, terahertz time domain spectroscopy (THz-TDS) is used to analyze how the geometry of a compact affects its pore structure (pore shape and orientation). By using flat-faced and biconvex compacts, it was evident from our analysis that pores tend to assume specific shapes and orientations based on the compact's geometry and this was found to significantly affect the extracted optical properties of samples prepared by mixing a material with polyethylene (PE) as diluent and subsequent compaction. However, such sensitivity to the pore properties opens a number of industrial applications such as for quality testing of pharmaceutical tablets. A comparison made between the PE based compacts and a set of pharmaceutical tablets prepared from the same formulation has revealed that flatfaced and biconvex compacts possess different pore geometries and hence different optical properties.

ORCID iDs

Bawuah, P., Dong, R., Al-Sharabi, M., Markl, D. ORCID logoORCID: https://orcid.org/0000-0003-0411-733X and Zeitler, J. A.;
  • Item type:Book Section
    ID code:72662
    Dates:
    Date
    Event
    21 September 2019
    Published
    7 June 2019
    Accepted
    Notes:© 2019 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting /republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
    Subjects:Medicine > Pharmacy and materia medica
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:10 Jun 2020 10:19
    Last modified:11 Nov 2024 15:21
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/72662
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