The modifying effect of supramolecular gel fibres on the diffusion of paracetamol and ibuprofen sodium on the picosecond timescale
Edkins, Robert M. and Appel, Markus and Seydel, Tilo and Edkins, Katharina (2020) The modifying effect of supramolecular gel fibres on the diffusion of paracetamol and ibuprofen sodium on the picosecond timescale. Physical Chemistry Chemical Physics, 22 (19). pp. 10838-10844. ISSN 1463-9084 (https://doi.org/10.1039/D0CP01240H)
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Abstract
Employing neutron spectroscopy, we follow the tracer diffusion of two non-steroidal anti-inflammatory drug molecules, paracetamol (PCM) and ibuprofen sodium (IBU), in a supramolecular gel and the corresponding bulk solution. Both solutes show altered diffusion behaviour in the gel phase, deviating from each other and their bulk solution. Whilst picosecond diffusion of IBU is slightly quicker in the gel, this effect is significantly increased for PCM, which is up to 70% quicker in the gel than in solution.This effect is independent of changes in the solvent diffusion reported previously. An increased residence time of PCM in solution at lower temperatures points towards the onset of nucleation and crystallisation. This work reports one of the first experiments on the novel Backscattering and Time-of-Flight option (BATS) on the IN16B spectrometer at the Institut Laue-Langevin, France, which with its range and resolution in neutron energy and momentum transfer is ideally suited to observe this type of diffusion.
ORCID iDs
Edkins, Robert M. ORCID: https://orcid.org/0000-0001-6117-5275, Appel, Markus, Seydel, Tilo and Edkins, Katharina ORCID: https://orcid.org/0000-0002-6885-5457;-
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Item type: Article ID code: 72128 Dates: DateEvent21 May 2020Published20 April 2020Published Online20 April 2020Accepted4 March 2020SubmittedSubjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical SciencesDepositing user: Pure Administrator Date deposited: 22 Apr 2020 11:48 Last modified: 27 Sep 2024 01:16 URI: https://strathprints.strath.ac.uk/id/eprint/72128