The effect of tissue-mimicking phantom compressibility on magnetic hyperthermia
Kaczmarek, Katarzyna and Mrówczyński, Radosław and Hornowski, Tomasz and Bielas, Rafał and Józefczak, Arkadiusz (2019) The effect of tissue-mimicking phantom compressibility on magnetic hyperthermia. Nanomaterials, 9 (5). 803. ISSN 2079-4991
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Abstract
During hyperthermia, magnetite nanoparticles placed in an AC magnetic field become a source of heat. It has been shown that in fluid suspensions, magnetic particles move freely and generate heat easily. However, in tissues of different mechanical properties, nanoparticle movement is limited and leads to a small temperature rise in tissue. Therefore, it is crucial to conduct magnetic hyperthermia experiments in similar conditions to the human body. The effect of tissue-mimicking phantom compressibility on the effectiveness of magnetic hyperthermia was investigated on agar phantoms. Single and cluster nanoparticles were synthesized and used as magnetic materials. The prepared magnetic materials were characterized by transmission electron microscopy (TEM), and zeta potential measurements. Results show that tissue-mimicking phantom compressibility decreases with the concentration of agar. Moreover, the lower the compressibility, the lower the thermal effect of magnetic hyperthermia. Specific absorption rate (SAR) values also proved our assumption that tissue-mimicking phantom compressibility affects magnetic losses in the alternating magnetic field (AMF).
ORCID iDs
Kaczmarek, Katarzyna
ORCID: https://orcid.org/0000-0002-3193-0070, Mrówczyński, Radosław, Hornowski, Tomasz, Bielas, Rafał and Józefczak, Arkadiusz;
Item type: Article ID code: 71966 Dates: DateEvent25 May 2019Published23 May 2019AcceptedKeywords: magnetic nanoparticles, magnetic hyperthermia, Brown relaxation, compressibility, tissue-mimicking phantom, Bioengineering, Biomedical Engineering Subjects: Technology > Engineering (General). Civil engineering (General) > Bioengineering Department: Faculty of Engineering > Biomedical Engineering Depositing user: Pure Administrator Date deposited: 02 Apr 2020 14:00 Last modified: 21 Jan 2021 11:48 URI: https://strathprints.strath.ac.uk/id/eprint/71966
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)