Computational investigation in the aorta of children with Turner syndrome

Johnston, Lauren and Allen, Ruth and Hall-Barrientos, Pauline and Mason, Avril and Kazakidi, Asimina (2019) Computational investigation in the aorta of children with Turner syndrome. In: CMALS One Health Workshop, 2019-12-12 - 2019-12-12, University of Strathclyde.

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    Abstract

    The aortic arch has complex flow dynamics, with locations of arterial curvature and bifurcation known to be prone to endothelial dysfunction one of the early biological markers for atherosclerotic lesions that underlie most cardiovascular disease. This is particularly relevant to conditions of obesity, which is believed to accelerate the initiation and progression of vascular changes. A computational investigation found morphological differences between the patient-specific geometries to have a strong effect on the haemodynamic environment, and low wall shear stress at areas where atherosclerotic lesions have been suggested to develop preferentially.