Multi-parameter computational model of flow mediated dilation with fluid-structure interaction coupled with lumped parameter approaches

Hyde-Linaker, George and Black, Richard Anthony and Flamini, Vittoria and Kazakidi, Asimina (2020) Multi-parameter computational model of flow mediated dilation with fluid-structure interaction coupled with lumped parameter approaches. In: 14th World Congress in Computational Mechanics, 2020-07-19 - 2020-07-24. (In Press)

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Abstract

Flow-mediated dilation (FMD) is a valuable non-invasive clinical assessment of endothelial dysfunction, a key indicator of atherosclerosis. The progression of atherosclerosis from paediatric ages can lead to the manifestation of cardiovascular diseases (CVDs) in later life. Hence, early lesion detection in younger years using FMD will heavily support timely disease assessment and treatment. In FMD, the diameter of the brachial artery is measured ultrasonically before, during, and after the inflation of a cuff applied to the lower arm of a subject. The cuff is placed distal to the ultrasound probe to capture predominantly endothelium-dependent vasodilation [1].The process induces a period of reactive hyperaemia, causing the brachial artery to vasodilate, due to an increase in shear stress that results in release of nitric oxide. The brachial artery ‘speak dilation is used for calculating the percentage difference between peak and baseline diameter (FMD percentage).Modelling FMD computationally offers a non-invasive assessment of vascular health and haemodynamic parameters.

  • Item type:Conference or Workshop Item(Other)
    ID code:71812
    Dates:
    Date
    Event
    28 February 2020
    Published
    28 February 2020
    Accepted
    15 January 2020
    Submitted
    Subjects:Medicine > Internal medicine
    Department:Faculty of Engineering > Biomedical Engineering
    Depositing user: Pure Administrator
    Date deposited:19 Mar 2020 12:13
    Last modified:09 Apr 2024 06:47
    URI:https://strathprints.strath.ac.uk/id/eprint/71812
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