Surface design for immobilization of an antimicrobial peptide mimic for efficient anti‐biofouling
Hasan, Abshar and Lee, Kyueui and Tewari, Kunal and Pandey, Lalit M. and Messersmith, Phillip B. and Faulds, Karen and MacLean, Michelle and Lau, King Hang Aaron (2020) Surface design for immobilization of an antimicrobial peptide mimic for efficient anti‐biofouling. Chemistry - A European Journal, 26 (26). pp. 5789-5793. ISSN 1521-3765 (https://doi.org/10.1002/chem.202000746)
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Abstract
Microbial surface attachment negatively impacts a wide range of devices from water purification membranes to biomedical implants. Mimics of antimicrobial peptides (AMPs) constituted from poly(N‐substituted glycine) "peptoids" are of great interest as they resist proteolysis and can inhibit a wide spectrum of microbes. We investigate how terminal modification of a peptoid AMP‐mimic and its surface immobilization affect antimicrobial activity. We also demonstrate a convenient surface modification scheme for enabling alkyne‐azide "click" coupling on amino‐functionalized surfaces. Our results verified that the N‐ and C‐terminal peptoid structures are not required for antimicrobial activity. Moreover, our peptoid immobilization density and choice of PEG tether resulted in a "volumetric" spatial separation between AMPs that, compared to past studies, enabled the highest AMP surface activity relative to bacterial attachment. Our analysis suggests the importance of spatial flexibility for membrane activity and that AMP separation may be a controlling parameter for optimizing surface anti‐biofouling.
ORCID iDs
Hasan, Abshar, Lee, Kyueui, Tewari, Kunal, Pandey, Lalit M., Messersmith, Phillip B., Faulds, Karen ORCID: https://orcid.org/0000-0002-5567-7399, MacLean, Michelle ORCID: https://orcid.org/0000-0001-5750-0397 and Lau, King Hang Aaron ORCID: https://orcid.org/0000-0003-3676-9228;-
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Item type: Article ID code: 71753 Dates: DateEvent7 May 2020Published14 February 2020Published Online13 February 2020AcceptedSubjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry
Strategic Research Themes > Health and Wellbeing
Technology and Innovation Centre > Bionanotechnology
Faculty of Engineering > Electronic and Electrical EngineeringDepositing user: Pure Administrator Date deposited: 12 Mar 2020 12:22 Last modified: 11 Nov 2024 12:37 URI: https://strathprints.strath.ac.uk/id/eprint/71753