Silver-nanoparticle-mediated therapies in the treatment of pancreatic cancer

Foulkes, Rachel and Ali Asgari, Mohsen and Curtis, Anthony and Hoskins, Clare (2019) Silver-nanoparticle-mediated therapies in the treatment of pancreatic cancer. ACS Applied Nano Materials, 2 (4). pp. 1758-1772. (

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Pancreatic cancer is an extremely aggressive disease for which patient prognosis is poor and survival is extremely unlikely. It is an extremely under-represented cancer in the research field because of the dense tumors formed and complexities surrounding treatment requirements. The use of nanomedicines in cancer therapy has been explored over the past few decades. Such nanomedicines are slowly coming to fruition in the clinical setting. One such platform that may possess promise in the fight against pancreatic cancer is the use of colloidal silver. Silver nanoparticles have shown potential in other cancer types over a host of treatment strategies, and these are likely to be translatable into pancreatic cancer. This review will focus on the potential use of silver nanoparticles in pancreatic cancer therapy, reporting on a range of different strategies being employed that may be directly applicable in the improvement of clinical outcomes for pancreatic cancer patients.