Syntaxin 16 is a master recruitment factor for cytokinesis

Neto, Hélia and Kaupisch, Alexandra and Collins, Louise L. and Gould, Gwyn W. (2013) Syntaxin 16 is a master recruitment factor for cytokinesis. Molecular Biology of the Cell, 24 (23). pp. 3663-3674. ISSN 1059-1524

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    Abstract

    Recently it was shown that both recycling endosome and endosomal sorting complex required for transport (ESCRT) components are required for cytokinesis, in which they are believed to act in a sequential manner to bring about secondary ingression and abscission, respectively. However, it is not clear how either of these complexes is targeted to the midbody and whether their delivery is coordinated. The trafficking of membrane vesicles between different intracellular organelles involves the formation of soluble N-ethylmaleimide- sensitive factor attachment protein receptor (SNARE) complexes. Although membrane traffic is known to play an important role in cytokinesis, the contribution and identity of intracellular SNAREs to cytokinesis remain unclear. Here we demonstrate that syntaxin 16 is a key regulator of cytokinesis, as it is required for recruitment of both recycling endosome-associated Exocyst and ESCRT machinery during late telophase, and therefore that these two distinct facets of cytokinesis are inextricably linked.

    Creators(s): Neto, Hélia, Kaupisch, Alexandra, Collins, Louise L. and Gould, Gwyn W. ORCID logoORCID: https://orcid.org/0000-0001-6571-2875;
    Item type:Article
    ID code:70425
    Keywords:cytokinesis, intracellular organelles, SNARE, membrane traffic, Microbiology, Molecular Biology, Cell Biology
    Subjects:Science > Microbiology
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:05 Nov 2019 12:06
    Last modified:21 Jan 2021 11:24
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/70425
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