Cystic fibrosis patient monitor
Donnelly, S. and Ward, A.C. and MacGregor, G. and Connolly, P.; (2019) Cystic fibrosis patient monitor. In: BioMedEng19 Conference Proceedings. BioMedEng, GBR, p. 78. ISBN 9781999646523
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Abstract
Cystic Fibrosis (CF) is a genetic disease which affects the body’s ability to regulate chloride movement across epithelial cells, leading to life-limiting conditions such as chronic airway infection and pancreatic disease. Treatments for CF are emerging which aim to correct and enhance the underlying CFTR protein dysfunction which causes the disease. Sweat Cl- concentration is a key biomarker in gauging the efficacy of such treatments. To be able to measure Clin sweat non-invasively in real time, we are developing a wearable, chloride-sensitive patch. This study shows that pHEMA-adapted electrodes can be used to successfully detect clinically relevant changes in Cl- concentration. Studies carried out with an in vitro cell suggest that the electrodes could be used as part of a wearable device capable of monitoring transdermal chloride concentrations. Such a device would play a vital role in monitoring the impact emerging CF treatments have on CFTR functionality, the underlying cause of CF.
ORCID iDs
Donnelly, S. ORCID: https://orcid.org/0000-0002-7089-6645, Ward, A.C. ORCID: https://orcid.org/0000-0002-5302-5899, MacGregor, G. and Connolly, P.;-
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Item type: Book Section ID code: 70272 Dates: DateEvent5 September 2019Published28 June 2019AcceptedSubjects: Technology > Engineering (General). Civil engineering (General) > Bioengineering Department: Faculty of Engineering > Biomedical Engineering Depositing user: Pure Administrator Date deposited: 24 Oct 2019 15:53 Last modified: 01 Oct 2024 00:11 URI: https://strathprints.strath.ac.uk/id/eprint/70272