Population genetics of 30 insertion/deletion polymorphisms in the Kuwaiti population

Haidar, Mahdi and Alsaleh, Hussain and Haddrill, Penelope R. (2019) Population genetics of 30 insertion/deletion polymorphisms in the Kuwaiti population. International Journal of Legal Medicine. ISSN 0937-9827 (https://doi.org/10.1007/s00414-019-02180-4)

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Abstract

This study evaluates the forensic utility of the 30 insertion and deletion (indel) markers contained in the Qiagen Investigator® DIPplex kit in the Kuwaiti population (n = 150). All but one of the 30 markers were shown to conform to the expectations of the Hardy-Weinberg Equilibrium. Linkage disequilibrium tests showed no statistically significant deviation from independence. The high combined power of discrimination (CPD > 99.999%) and low combined match probability (CMP) of 2.736 × 10 −13 provide a satisfactory level of discrimination, allowing the DIPplex loci to be used as forensic markers for individual identification in Kuwait. The paternity indices indicate the usefulness of the DIPplex kit as a supplementary typing system for challenging paternity cases in Kuwait.

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