Multisite microLED optrode array for neural interfacing
McAlinden, Niall and Cheng, Yunzhou and Scharf, Robert and Xie, Enyuan and Gu, Erdan and Reiche, Christopher F. and Sharma, Rohit and Tathireddy, Prashant and Dawson, Martin D. and Rieth, Loren and Blair, Steve and Mathieson, Keith (2019) Multisite microLED optrode array for neural interfacing. Neurophotonics, 6 (3). 035010. (https://doi.org/10.1117/1.NPh.6.3.035010)
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Abstract
We present an electrically addressable optrode array capable of delivering light to 181 sites in the brain, each providing sufficient light to optogenetically excite thousands of neurons in vivo, developed with the aim to allow behavioral studies in large mammals. The device is a glass microneedle array directly integrated with a custom fabricated microLED device, which delivers light to 100 needle tips and 81 interstitial surface sites, giving two-level optogenetic excitation of neurons in vivo. Light delivery and thermal properties are evaluated, with the device capable of peak irradiances >80 mW / mm2 per needle site. The device consists of an array of 181 80 μm × 80 μm2 microLEDs, fabricated on a 150-μm-thick GaN-on-sapphire wafer, coupled to a glass needle array on a 150-μm thick backplane. A pinhole layer is patterned on the sapphire side of the microLED array to reduce stray light. Future designs are explored through optical and thermal modeling and benchmarked against the current device.
ORCID iDs
McAlinden, Niall ORCID: https://orcid.org/0000-0002-0369-8788, Cheng, Yunzhou ORCID: https://orcid.org/0000-0001-7366-4893, Scharf, Robert, Xie, Enyuan ORCID: https://orcid.org/0000-0001-7776-8091, Gu, Erdan ORCID: https://orcid.org/0000-0002-7607-9902, Reiche, Christopher F., Sharma, Rohit, Tathireddy, Prashant, Dawson, Martin D. ORCID: https://orcid.org/0000-0002-6639-2989, Rieth, Loren, Blair, Steve and Mathieson, Keith ORCID: https://orcid.org/0000-0002-9517-8076;-
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Item type: Article ID code: 69677 Dates: DateEvent28 August 2019Published5 August 2019AcceptedSubjects: Science > Physics Department: Faculty of Science > Physics > Institute of Photonics
Faculty of Science > PhysicsDepositing user: Pure Administrator Date deposited: 06 Sep 2019 10:10 Last modified: 11 Nov 2024 12:25 URI: https://strathprints.strath.ac.uk/id/eprint/69677