Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling

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Lin, Hungyen and Pei, Chunlei and Markl, Daniel and Shen, Yaochun and Elliott, James A. and Axel Zeitler, J. (2018) Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling. IET Microwaves, Antennas and Propagation, 12 (11). pp. 1775-1779. ISSN 1751-8725 (https://doi.org/10.1049/iet-map.2018.5561)

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Abstract

In recent years, terahertz in-line sensing has been used to monitor the film coating thickness of individual pharmaceutical tablets during the coating process. In the previous work, the in-line measurements were verified against off-line measurements of samples from the same population. Here, we report on our recent progress to further verify the validity of the terahertz in-line measurement modality using discrete element modelling for an artificial lab-scale tablet mixing process inside a tablet pan coater. By coupling discrete modelling with a ray-tracing method, it is then possible to estimate the cumulative measurements taken, which in turn can guide towards the fine-tuning of the selection criteria as part of measurement analysis.

ORCID iDs

Lin, Hungyen, Pei, Chunlei, Markl, Daniel ORCID logoORCID: https://orcid.org/0000-0003-0411-733X, Shen, Yaochun, Elliott, James A. and Axel Zeitler, J.;
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