Splice-switching small molecules : a new therapeutic approach to modulate gene expression
Taladriz-Sender, Andrea and Campbell, Emma and Burley, Glenn A. (2019) Splice-switching small molecules : a new therapeutic approach to modulate gene expression. [Review]
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Text (Taladriz-Sender-etal-Methods-2019-Splice-switching-small-molecules-a-new-therapeutic-approach)
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Official URL: https://doi.org/10.1016/j.ymeth.2019.06.011
Abstract
Manipulating alternative RNA splicing events with small molecules is emerging as a viable mechanism for the development of therapeutics. A salient challenge in the field is understanding the molecular determinants defining the selectivity of splice-switching events and their mechanisms of action. In this review, the current state-of-the-art in splice-switching small molecules is described. Three examples of splice-switching small molecules are presented, and the differences in their modes of action compared.
Creators(s): |
Taladriz-Sender, Andrea ![]() | Item type: | Review |
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ID code: | 68487 |
Keywords: | RNA splicing, small molecules, splice switching, Chemistry, Chemistry(all) |
Subjects: | Science > Chemistry |
Department: | Faculty of Science > Pure and Applied Chemistry |
Depositing user: | Pure Administrator |
Date deposited: | 18 Jun 2019 14:32 |
Last modified: | 01 Jan 2021 13:06 |
Related URLs: | |
URI: | https://strathprints.strath.ac.uk/id/eprint/68487 |
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