Splice-switching small molecules : a new therapeutic approach to modulate gene expression

Taladriz-Sender, Andrea and Campbell, Emma and Burley, Glenn A. (2019) Splice-switching small molecules : a new therapeutic approach to modulate gene expression. [Review]

[img]
Preview
 Text (Taladriz-Sender-etal-Methods-2019-Splice-switching-small-molecules-a-new-therapeutic-approach)
Taladriz_Sender_etal_Methods_2019_Splice_switching_small_molecules_a_new_therapeutic_approach.pdf
Accepted Author Manuscript
License: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 logo
Download (1MB)| Preview

    Abstract

    Manipulating alternative RNA splicing events with small molecules is emerging as a viable mechanism for the development of therapeutics. A salient challenge in the field is understanding the molecular determinants defining the selectivity of splice-switching events and their mechanisms of action. In this review, the current state-of-the-art in splice-switching small molecules is described. Three examples of splice-switching small molecules are presented, and the differences in their modes of action compared.

    Creators(s): Taladriz-Sender, Andrea ORCID logoORCID: https://orcid.org/0000-0002-8274-4761, Campbell, Emma and Burley, Glenn A.;
    Item type:Review
    ID code:68487
    Keywords:RNA splicing, small molecules, splice switching, Chemistry, Chemistry(all)
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:18 Jun 2019 14:32
    Last modified:21 Sep 2020 02:28
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/68487
    Export data:
    CORE (COnnecting REpositories)