Intracellular uptake of EGCG-loaded deformable controlled release liposomes for skin cancer
Marwah, M. and Perrie, Y. and Badhan, R. K.S. and Lowry, D. (2019) Intracellular uptake of EGCG-loaded deformable controlled release liposomes for skin cancer. Journal of Liposome Research. ISSN 0898-2104
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Abstract
Caucasian population groups have a higher propensity to develop skin cancer, and associated clinical interventions often present substantial financial burden on healthcare services. Conventional treatments are often not suitable for all patient groups as a result of poor efficacy and toxicity profiles. The primary objective of this study was to develop a deformable liposomal formulation, the properties of which being dictated by the surfactant Tween 20, for the dermal cellular delivery of epigallocatechin gallatein (EGCG), a compound possessing antineoplastic properties. The results demonstrated a significant (p ≤ 0.05) decrease in liposome deformability index (74 ± 8 to 37 ± 7) as Tween 20 loading increased from 0 to 10% w/w, indicating an increase in elasticity. EGCG release over 24-h demonstrated Tween 20 incorporation directly increased release from 13.7% ± 1.1% to 94.4% ± 4.9% (for 0 and 10% w/w Tween 20 respectively). Finally, we demonstrated DilC-loaded deformable liposomes were localized intracellularly within human dermal fibroblast and keratinocyte cells within 2 h. Thus, it was evident that deformable liposomes may aid drug penetration into dermal cells and would be useful in developing a controlled-release formulation.
Creators(s): | Marwah, M., Perrie, Y., Badhan, R. K.S. and Lowry, D.; | Item type: | Article |
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ID code: | 68362 |
Keywords: | controlled release, deformable liposomes, dermal release, elastic liposomes, Skin cancer, Pharmacy and materia medica, Pharmaceutical Science |
Subjects: | Medicine > Pharmacy and materia medica |
Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Faculty of Humanities and Social Sciences (HaSS) > School of Psychological Science and Health |
Depositing user: | Pure Administrator |
Date deposited: | 12 Jun 2019 09:31 |
Last modified: | 21 Jan 2021 10:59 |
Related URLs: | |
URI: | https://strathprints.strath.ac.uk/id/eprint/68362 |
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