Advances in Raman spectroscopy for the diagnosis of alzheimer's disease

Sudworth, C.D. and Archer, J.K.J. and Black, R.A. and Thalmann, D. (2006) Advances in Raman spectroscopy for the diagnosis of alzheimer's disease. Proceedings of SPIE: The International Society for Optical Engineering, 6093. pp. 139-146. (http://dx.doi.org/10.1117/12.642823)

Abstract

This research demonstrates the potential role of Raman spectroscopy, combined with principle components analysis (PCA), as a diagnostic method. Analyses of ethically approved ex vivo post-mortem brain tissues (originating from frontal and occipital lobes) from control (3 normal elderly subjects and 3 Huntingdon's disease subjects) and Alzheimer's disease (12 subjects) brain sections, and a further set of 12 blinded samples are presented. Spectra originating from these tissues are highly reproducible, and initial results indicate a vital difference in protein content and conformation, relating to the abnormally high levels of aggregated proteins in the diseased tissues. Further examination of these spectra using PCA allows for the separation of control from diseased tissues. The validation of the PCA models using blinded samples also displays promise for the identification of Alzheimer's disease, in conjunction with secondary information regarding other brain diseases and dementias. These results provide a route for Raman spectroscopy as a possible non-invasive, non-destructive tool for the early diagnosis of Alzheimer's disease.

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  Item type:	Article
  ID code:	6834
  Dates:	Date Event 2006 Published
  Notes:	Also published in Progress in biomedical optics and imaging. ISSN 1605-7422 Vol. 7, No. 16, 2006.
  Keywords:	alzheimer's disease, biotechnology, bioengineering, component analysis, brain, Bioengineering, Physiology, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, Electrical and Electronic Engineering, Applied Mathematics, Computer Science Applications
  Subjects:	Technology > Engineering (General). Civil engineering (General) > Bioengineering Science > Physiology
  Department:	Faculty of Engineering > Bioengineering
  Depositing user:	Strathprints Administrator
  Date deposited:	04 Sep 2008
  Last modified:	20 Sep 2022 09:20
  URI:	https://strathprints.strath.ac.uk/id/eprint/6834