Picture map of Europe with pins indicating European capital cities

Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

Explore research outputs by the European Policies Research Centre...

Strathprints

Advances in Raman spectroscopy for the diagnosis of alzheimer's disease

Sudworth, C.D. and Archer, J.K.J. and Black, R.A. and Thalmann, D. (2006) Advances in Raman spectroscopy for the diagnosis of alzheimer's disease. Proceedings of SPIE: The International Society for Optical Engineering, 6093. pp. 139-146.

Full text not available in this repository. Request a copy from the Strathclyde author

Abstract

This research demonstrates the potential role of Raman spectroscopy, combined with principle components analysis (PCA), as a diagnostic method. Analyses of ethically approved ex vivo post-mortem brain tissues (originating from frontal and occipital lobes) from control (3 normal elderly subjects and 3 Huntingdon's disease subjects) and Alzheimer's disease (12 subjects) brain sections, and a further set of 12 blinded samples are presented. Spectra originating from these tissues are highly reproducible, and initial results indicate a vital difference in protein content and conformation, relating to the abnormally high levels of aggregated proteins in the diseased tissues. Further examination of these spectra using PCA allows for the separation of control from diseased tissues. The validation of the PCA models using blinded samples also displays promise for the identification of Alzheimer's disease, in conjunction with secondary information regarding other brain diseases and dementias. These results provide a route for Raman spectroscopy as a possible non-invasive, non-destructive tool for the early diagnosis of Alzheimer's disease.

Item type: Article
ID code: 6834
Notes: Also published in Progress in biomedical optics and imaging. ISSN 1605-7422 Vol. 7, No. 16, 2006.
Keywords: alzheimer's disease, biotechnology, bioengineering, component analysis, brain, Bioengineering, Physiology, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, Electrical and Electronic Engineering, Applied Mathematics, Computer Science Applications
Subjects: Technology > Engineering (General). Civil engineering (General) > Bioengineering
Science > Physiology
Department: Faculty of Engineering > Bioengineering
Depositing user: Strathprints Administrator
Date deposited: 04 Sep 2008
Last modified: 22 Mar 2017 09:46
URI: https://strathprints.strath.ac.uk/id/eprint/6834
Export data:
CORE (COnnecting REpositories)