Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption : an UNGAP review
Vertzoni, Maria and Augustijns, Patrick and Grimm, Michael and Koziolek, Mirko and Lemmens, Glenn and Parrott, Neil and Pentafragka, Christina and Reppas, Christos and Rubbens, Jari and Van Den Αbeele, Jens and Vanuytsel, Tim and Weitschies, Werner and Wilson, Clive G. (2019) Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption : an UNGAP review. European Journal of Pharmaceutical Sciences, 134. pp. 153-175. ISSN 0928-0987 (https://doi.org/10.1016/j.ejps.2019.04.013)
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Abstract
Oral administration is the most common route of drug delivery. The absorption of a drug from the gut into the bloodstream involves disintegration of the solid dosage form, dissolution of the active pharmaceutical ingredient and its transport across the gut wall. The efficiency of these processes is determined by highly complex and dynamic interplay between the gastrointestinal tract, the dosage form and the API. The European Network on Understanding Gastrointestinal Absorption-related Processes (UNGAP)aims to improve our understanding of intestinal drug absorption by creating a multidisciplinary Network of researchers from academia and industry engaging in scientific discussions. As part of the basis for the UNGAP project, this review aims to summarize the current knowledge on anatomy and physiology of the human gastrointestinal tract with emphasis on human studies for the evaluation of the regional drug absorption and the prediction of oral dosage form performance. A range of factors and methods will be considered, including imaging methods, intraluminal sampling and, models for predicting segmental/regional absorption. In addition, in vitro and in silico methods to evaluate regional drug absorption will be discussed. This will provide the basis for further work on improving predictions for the in vivo behavior of drug products in the gastrointestinal tract.
ORCID iDs
Vertzoni, Maria, Augustijns, Patrick, Grimm, Michael, Koziolek, Mirko, Lemmens, Glenn, Parrott, Neil, Pentafragka, Christina, Reppas, Christos, Rubbens, Jari, Van Den Αbeele, Jens, Vanuytsel, Tim, Weitschies, Werner and Wilson, Clive G. ORCID: https://orcid.org/0000-0002-4211-7907;-
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Item type: Article ID code: 67946 Dates: DateEvent15 June 2019Published13 April 2019Published Online9 April 2019AcceptedSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Humanities and Social Sciences (HaSS) > Psychological Sciences and HealthDepositing user: Pure Administrator Date deposited: 22 May 2019 09:08 Last modified: 01 Oct 2024 10:14 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/67946