Assessment of drug incorporation and release from a novel coronary stent coating

McKittrick, Craig Martin and Dixon, Simon and McCormick, Christopher (2015) Assessment of drug incorporation and release from a novel coronary stent coating. In: 27th European Conference on Biomaterials, 2015-08-30 - 2015-09-03, ICE Krakow Congress Centre.

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    Abstract

    The introduction of drug eluting stents (DES) for the treatment of coronary heart disease has significantly reduced in-stent restenosis, however the use of cytostatic agents causes delayed re-endothelialisation of the target vessel. Here we describe the drug release profiles for rapamycin incorporated into a novel acrylic-based polymer designed to promote vascular re-endothelialisation. Understanding drug release from the surface of DES is integral to the stent development process. It is useful for testing the reliability and reproducibility of coatings and for providing insight into mechanisms of drug release.