Brain activation in highly superior autobiographical memory : the role of the precuneus in the autobiographical memory retrieval network
Mazzoni, Giuliana and Clark, Andrew and De Bartolo, Adriana and Guerrini, Chiara and Nahouli, Zacharia and Duzzi, Davide and De Marco, Matteo and McGeown, William and Venneri, Annalena (2019) Brain activation in highly superior autobiographical memory : the role of the precuneus in the autobiographical memory retrieval network. Cortex, 120. pp. 588-602. ISSN 0010-9452 (https://doi.org/10.1016/j.cortex.2019.02.020)
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Abstract
This is the first study to examine functional brain activation in a single case of Highly Superior Autobiographical Memory (HSAM) who shows no sign of obsessive compulsive disorder (OCD). While previous work has documented the existence of HSAM, information about brain areas involved in this exceptional form of memory for personal events relies on structural and resting state connectivity data, with mixed results so far. In this first task-based functional magnetic resonance Imaging (fMRI) study of a normal individual with HSAM, dates were presented as cues and two phases were assessed during memory retrieval, initial access and later elaboration. Results showed that initial access was very fast, did not activate the hippocampus, and involved activation of predominantly posterior visual areas, including the precuneus. These areas typically become active during later stages of elaboration of personal memories rather than during initial access. Elaboration involved a balanced bilateral activation of most of the autobiographical network areas, rather than the more typical shifts observed in people without HSAM. Overall, the pattern of brain activations, which rests on repeated observations in a single individual, highlights a strong involvement of the precuneus and an idiosyncratic initial access to personal memory representations. Implications for the nature of personal memories in HSAM are discussed.
ORCID iDs
Mazzoni, Giuliana, Clark, Andrew, De Bartolo, Adriana, Guerrini, Chiara, Nahouli, Zacharia, Duzzi, Davide, De Marco, Matteo, McGeown, William ORCID: https://orcid.org/0000-0001-7943-5901 and Venneri, Annalena;-
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Item type: Article ID code: 67268 Dates: DateEvent1 November 2019Published5 March 2019Published Online16 February 2019AcceptedSubjects: Medicine > Internal medicine > Neuroscience. Biological psychiatry. Neuropsychiatry Department: Faculty of Humanities and Social Sciences (HaSS) > Psychological Sciences and Health > Psychology Depositing user: Pure Administrator Date deposited: 12 Mar 2019 11:38 Last modified: 03 Oct 2024 00:29 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/67268