Combining mathematical modelling with in-vitro experiments to predict in-vivo drug-eluting stent kinetics

McGinty, Sean and McCormick, Christopher and McKittrick, Craig Martin and Kennedy, Simon and Oldroyd, Keith G. and Wheel, Marcus and Scullion, Bryan and Pontrelli, Giuseppe and McKee, Sean (2017) Combining mathematical modelling with in-vitro experiments to predict in-vivo drug-eluting stent kinetics. In: 5th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017). Zeta Computational Resources Ltd., Swansea UK, pp. 1011-1014. ISBN 9780956291448

[img]
Preview
Text (McGinty-CMBE2017-in-vitro-in-vivo-drug-eluting-stent-kinetics)
McGinty_CMBE2017_in_vitro_in_vivo_drug_eluting_stent_kinetics.pdf
Final Published Version

Download (179kB)| Preview

    Abstract

    In this paper we describe a combined in-vitro experimental and mathematical modelling approach to predict in-vivo drug-eluting stent kinetics. We coated stents with a mixture of sirolimus and a novel acrylic-based polymer in two different ratios. Our results indicate differential release kinetics between low and high drug dose formulations. Furthermore, mathematical model simulations of target receptor saturation suggest potential differences in efficacy.