Combining mathematical modelling with in-vitro experiments to predict in-vivo drug-eluting stent kinetics
McGinty, Sean and McCormick, Christopher and McKittrick, Craig Martin and Kennedy, Simon and Oldroyd, Keith G. and Wheel, Marcus and Scullion, Bryan and Pontrelli, Giuseppe and McKee, Sean; Nithiarasu, P. and Robertson, A.M., eds. (2017) Combining mathematical modelling with in-vitro experiments to predict in-vivo drug-eluting stent kinetics. In: 5th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017). Zeta Computational Resources Ltd., USA, pp. 1011-1014. ISBN 9780956291448
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Abstract
In this paper we describe a combined in-vitro experimental and mathematical modelling approach to predict in-vivo drug-eluting stent kinetics. We coated stents with a mixture of sirolimus and a novel acrylic-based polymer in two different ratios. Our results indicate differential release kinetics between low and high drug dose formulations. Furthermore, mathematical model simulations of target receptor saturation suggest potential differences in efficacy.
Creators(s): |
McGinty, Sean, McCormick, Christopher, McKittrick, Craig Martin ![]() ![]() | Item type: | Book Section |
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ID code: | 67264 |
Keywords: | Drug-eluting stents, drug delivery, coupled partial differential equations, in-vivo experiments, Pharmacy and materia medica, Bioengineering, Biomedical Engineering |
Subjects: | Medicine > Pharmacy and materia medica Technology > Engineering (General). Civil engineering (General) > Bioengineering |
Department: | Faculty of Engineering > Biomedical Engineering Strategic Research Themes > Health and Wellbeing Faculty of Engineering > Mechanical and Aerospace Engineering Faculty of Science > Mathematics and Statistics |
Depositing user: | Pure Administrator |
Date deposited: | 12 Mar 2019 11:23 |
Last modified: | 27 Jan 2021 10:02 |
Related URLs: | |
URI: | https://strathprints.strath.ac.uk/id/eprint/67264 |
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