Picture of DNA strand

Pioneering chemical biology & medicinal chemistry through Open Access research...

Strathprints makes available scholarly Open Access content by researchers in the Department of Pure & Applied Chemistry, based within the Faculty of Science.

Research here spans a wide range of topics from analytical chemistry to materials science, and from biological chemistry to theoretical chemistry. The specific work in chemical biology and medicinal chemistry, as an example, encompasses pioneering techniques in synthesis, bioinformatics, nucleic acid chemistry, amino acid chemistry, heterocyclic chemistry, biophysical chemistry and NMR spectroscopy.

Explore the Open Access research of the Department of Pure & Applied Chemistry. Or explore all of Strathclyde's Open Access research...

Measuring secondary nucleation through single crystal seeding

Briuglia, Maria L. and Sefcik, Jan and Horst, Joop H. ter (2019) Measuring secondary nucleation through single crystal seeding. Crystal Growth and Design, 19 (1). pp. 421-429. ISSN 1528-7483

[img] Text (Briuglia-etal-CGD-2019-Measuring-secondary-nucleation-through-single-crystal-seeding)
Briuglia_etal_CGD_2019_Measuring_secondary_nucleation_through_single_crystal_seeding.pdf
Accepted Author Manuscript
Restricted to Repository staff only until 20 November 2019.

Download (1MB) | Request a copy from the Strathclyde author

    Abstract

    This article presents a novel assessment method for secondary nucleation rates using a well-controlled, small scale seeding procedure. The procedure comprises the seeding of a well-monitored, stirred, supersaturated solution by a carefully selected single crystal under conditions at which spontaneous nucleation does not occur. The determined number of particles in time were translated to a suspension density using a calibration performed with monodisperse polymer spheres. The increasing crystal suspension density in time subsequently allowed the determination of the secondary nucleation rate under very specific conditions of supersaturation and temperature. The secondary nucleation rate was measured as a function of seed crystal size and supersaturation. It was observed that the time elapsed between the moment a single seed crystal is added and the moment the suspension density started to increase is larger when the seeded crystals are smaller and the supersaturation is lower. A systematic study of secondary nucleation at different supersaturations led to the determination of a supersaturation threshold for secondary nucleation, which could be used in industrial crystallization process design to identify process conditions with the right secondary nucleation rate behavior.