How does toxoplasmosis affect the maternal-foetal immune interface and pregnancy?

Borges, Margarida and Silva, Tânia Magalhães and Brito, Carina and Teixeira, Natércia and Roberts, Craig W. (2018) How does toxoplasmosis affect the maternal-foetal immune interface and pregnancy? Parasite Immunology. e12606. ISSN 0141-9838

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    Abstract

    Toxoplasma gondii is a zoonotic parasite which, depending on the geographical location, can infect between 10 to 90% of humans. Infection during pregnancy mayresult in congenital toxoplasmosis. The effects on the fetus vary depending on the stage of gestation in which primary maternal infection arises. A large body of research has focused on understanding immune response to toxoplasmosis, although few studies have addressed how it is affected by pregnancy or the pathological consequences of infection at the maternal-fetal interface. There isa lack of knowledge about how maternal immune cells, specifically macrophages are modulated during infection and the resulting consequences for parasite control and pathology. Herein, we discuss the potential of T. gondii infection to affect the maternal-fetal interface and the potential of pregnancy to disrupt maternal immunity to T. gondii infection.