How does toxoplasmosis affect the maternal-foetal immune interface and pregnancy?

Borges, Margarida and Silva, Tânia Magalhães and Brito, Carina and Teixeira, Natércia and Roberts, Craig W. (2018) How does toxoplasmosis affect the maternal-foetal immune interface and pregnancy? Parasite Immunology. e12606. ISSN 0141-9838 (https://doi.org/10.1111/pim.12606)

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Abstract

Toxoplasma gondii is a zoonotic parasite which, depending on the geographical location, can infect between 10 to 90% of humans. Infection during pregnancy mayresult in congenital toxoplasmosis. The effects on the fetus vary depending on the stage of gestation in which primary maternal infection arises. A large body of research has focused on understanding immune response to toxoplasmosis, although few studies have addressed how it is affected by pregnancy or the pathological consequences of infection at the maternal-fetal interface. There isa lack of knowledge about how maternal immune cells, specifically macrophages are modulated during infection and the resulting consequences for parasite control and pathology. Herein, we discuss the potential of T. gondii infection to affect the maternal-fetal interface and the potential of pregnancy to disrupt maternal immunity to T. gondii infection.

ORCID iDs

Borges, Margarida, Silva, Tânia Magalhães, Brito, Carina, Teixeira, Natércia and Roberts, Craig W. ORCID logoORCID: https://orcid.org/0000-0002-0653-835X;
  • Item type:Article
    ID code:66219
    Dates:
    Date
    Event
    24 November 2018
    Published
    24 November 2018
    Published Online
    20 November 2018
    Accepted
    Notes:This is the peer reviewed version of the following article: Borges, M, Silva, TM, Brito, C, Teixeira, N & Roberts, CW 2018, 'How does Toxoplasmosis affect the maternal-fetal immune interface and pregnancy?' Parasite Immunology., which has been published in final form at https://doi.org/10.1111/pim.12606. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
    Subjects:Science > Microbiology > Immunology
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:27 Nov 2018 10:08
    Last modified:11 Nov 2024 12:09
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/66219
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