Incidence of submacular haemorrhage (SMH) in Scotland : a Scottish Ophthalmic Surveillance Unit (SOSU) study

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Al-Hity, Aws and Steel, David H and Yorston, David and Gilmour, David and Koshy, Zachariah and Young, David and Hillenkamp, Jost and McGowan, Gerard (2018) Incidence of submacular haemorrhage (SMH) in Scotland : a Scottish Ophthalmic Surveillance Unit (SOSU) study. Eye. ISSN 0950-222X (https://doi.org/10.1038/s41433-018-0239-4)

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Abstract

PURPOSE: Submacular haemorrhage (SMH) is a cause of severe visual loss in neovascular age-related macular degeneration (nAMD). The incidence is uncertain and furthermore there is no widely used classification system nor agreed best practice. The aim of this national surveillance study was to identify the incidence, presenting features and clinical course of new fovea-involving submacular haemorrhage associated with nAMD. METHODS: A questionnaire was sent monthly to every ophthalmic specialist in Scotland over a 12-month period asking them to report all newly presenting patients with acute SMH secondary to nAMD of at least two disc diameters (DDs) in greatest linear diameter. A follow-up questionnaire was sent 6 months after initial presentation. Cases related to other causes were excluded. RESULTS: Twenty-nine cases were reported giving an incidence of 5.4 per million per annum (range 2-15). The mean age was 83 years (range 66-96) and females accounted for 17/29 (59%). Fifteen of the 29 cases (52%) had a past history of AMD, of which 7 had nAMD. Nineteen of the 29 cases (66%) presented within 7 days of onset and the majority had SMH of < 11 DD (20/29, 69%). Treatment options comprised the following: observation (n = 6, 21%), anti-VEGF alone (n = 6, 21%) or vitrectomy with co-application of tissue plasminogen activator (TPA), anti-VEGF and gas (n = 17, 58%). The vitrectomy group experienced the greatest change in vision from logMAR 1.89-1.50 (p = 0.374). Four of 20 (20%) cases with 6 months follow-up suffered a re-bleed at a mean time of 96 days. CONCLUSIONS: The incidence, clinical features and course of a consecutive national cohort of patients with SMH secondary to nAMD are presented.

ORCID iDs

Al-Hity, Aws, Steel, David H, Yorston, David, Gilmour, David, Koshy, Zachariah, Young, David ORCID logoORCID: https://orcid.org/0000-0002-3652-0513, Hillenkamp, Jost and McGowan, Gerard;
  • Item type:Article
    ID code:66201
    Dates:
    Date
    Event
    29 October 2018
    Published
    29 October 2018
    Published Online
    7 August 2018
    Accepted
    Subjects:Medicine > Ophthalmology
    Department:Faculty of Science > Mathematics and Statistics
    Depositing user: Pure Administrator
    Date deposited:22 Nov 2018 15:13
    Last modified:26 Nov 2024 12:21
    URI:https://strathprints.strath.ac.uk/id/eprint/66201
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