Biocatalytic atom transfer radical polymerization in a protein cage nanoreactor

Renggli, Kasper and Sauter, Nora and Rother, Martin and Nussbaumer, Martin G. and Urbani, Raphael and Pfohl, Thomas and Bruns, Nico (2017) Biocatalytic atom transfer radical polymerization in a protein cage nanoreactor. Polymer Chemistry, 8 (14). pp. 2133-2136. ISSN 1759-9954

[thumbnail of Renggli-etal-PC-2017-Biocatalytic-atom-transfer-radical-polymerization-in-a-protein]
Preview
 Text (Renggli-etal-PC-2017-Biocatalytic-atom-transfer-radical-polymerization-in-a-protein)
Renggli_etal_PC_2017_Biocatalytic_atom_transfer_radical_polymerization_in_a_protein.pdf
Accepted Author Manuscript
Download (2MB)| Preview

    Abstract

    Incorporation of the ATRP-catalyzing enzyme horseradish peroxidase (HRP) into the cavities of the group II chaperonin thermosome is demonstrated. The resulting nanoreactor was used to polymerize an acrylate under ARGET ATRP conditions. The confined space within the protein cage results in poly(ethylene glycol) methyl ether acrylate (PEGA) with lower molecular weights (poly(styrene)-apparent Mn = 4400 g mol-1) as well as narrower molecular weight distributions (Đ = 1.08) compared to polymerizations with the free ATRPase (Mn = 43700 g mol-1 and a Đ of 1.23).

    ORCID iDs

    Renggli, Kasper, Sauter, Nora, Rother, Martin, Nussbaumer, Martin G., Urbani, Raphael, Pfohl, Thomas and Bruns, Nico ORCID logoORCID: https://orcid.org/0000-0001-6199-9995;
    • Item type:Article
      ID code:66178
      Dates:
      Date
      Event
      14 April 2017
      Published
      13 March 2017
      Published Online
      10 March 2017
      Accepted
      Keywords:horseradish peroxidase, protein cages, polymerization, Chemistry, Bioengineering, Biochemistry, Biomedical Engineering, Polymers and Plastics, Organic Chemistry
      Subjects:Science > Chemistry
      Department:Faculty of Science > Pure and Applied Chemistry
      Depositing user: Pure Administrator
      Date deposited:21 Nov 2018 09:56
      Last modified:23 Jul 2021 02:29
      Related URLs:
      URI:https://strathprints.strath.ac.uk/id/eprint/66178
    CORE (COnnecting REpositories)