Biocatalytic atom transfer radical polymerization in a protein cage nanoreactor

Renggli, Kasper and Sauter, Nora and Rother, Martin and Nussbaumer, Martin G. and Urbani, Raphael and Pfohl, Thomas and Bruns, Nico (2017) Biocatalytic atom transfer radical polymerization in a protein cage nanoreactor. Polymer Chemistry, 8 (14). pp. 2133-2136. ISSN 1759-9954 (https://doi.org/10.1039/c6py02155g)

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Abstract

Incorporation of the ATRP-catalyzing enzyme horseradish peroxidase (HRP) into the cavities of the group II chaperonin thermosome is demonstrated. The resulting nanoreactor was used to polymerize an acrylate under ARGET ATRP conditions. The confined space within the protein cage results in poly(ethylene glycol) methyl ether acrylate (PEGA) with lower molecular weights (poly(styrene)-apparent Mn = 4400 g mol-1) as well as narrower molecular weight distributions (Đ = 1.08) compared to polymerizations with the free ATRPase (Mn = 43700 g mol-1 and a Đ of 1.23).

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