Mapping memory binding onto the connectome's temporal dynamics : toward a combined biomarker for Alzheimer's disease
Ibanez, Agustin and Parra, Mario A. (2014) Mapping memory binding onto the connectome's temporal dynamics : toward a combined biomarker for Alzheimer's disease. Frontiers in Human Neuroscience, 8. 237. ISSN 1662-5161 (https://doi.org/10.3389/fnhum.2014.00237)
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Abstract
The classical amyloid cascade hypothesis of Alzheimer's disease (AD) has driven research and clinical practice for several decades. It states that the deposition of the amyloid-β peptide in the brain parenchyma initiates a sequence of events that ultimately lead to atrophy and AD dementia. This proposal stimulated the study of specific brain regions mapped along the neurodegeneration sequence (e.g., hippocampus) and their associated impaired functions (e.g., episodic memory). Although anticipated by Mesulam more than 20 years ago (e.g., Mesulam and Asuncion Moran, 1987), it was not until recently that this view has started to change, largely due to the disappointing results of trials relying on the beta-amyloid cascade hypothesis and its variants, e.g., the synaptic beta-amyloid hypothesis.
ORCID iDs
Ibanez, Agustin and Parra, Mario A. ORCID: https://orcid.org/0000-0002-2412-648X;-
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Item type: Article ID code: 65811 Dates: DateEvent22 April 2014Published1 April 2014AcceptedSubjects: Medicine > Internal medicine > Neuroscience. Biological psychiatry. Neuropsychiatry Department: Faculty of Humanities and Social Sciences (HaSS) > Psychological Sciences and Health > Psychology Depositing user: Pure Administrator Date deposited: 16 Oct 2018 12:36 Last modified: 03 Oct 2024 00:29 URI: https://strathprints.strath.ac.uk/id/eprint/65811