Haemodynamic analysis in arterial models in relation to pulmonary valve treatment in adults with congenital heart disease

Boumpouli, Maria and Danton, Mark and Gourlay, Terence and Kazakidi, Asimina (2018) Haemodynamic analysis in arterial models in relation to pulmonary valve treatment in adults with congenital heart disease. In: 13th World Congress in Computational Mechanics, 2018-07-22 - 2018-07-27, New York city.

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Abstract

Introduction Pulmonary artery stenting and valve replacement (PVR) are common interventions in an increasing population of adult patients with previously repaired congenital heart disease [1]. Indications for intervention include assessing regional haemodynamics and effects on right ventricular volume and function [2]. The criterion for intervention remains largely empirical and the optimal timing remains unknown. This work aims to investigate the altered haemodynamic environment of adults with congenital heart disease, pre- and post- operative PVR to establish a computational fluid dynamic (CFD) derived metric for determining the optimal requirement for PVR and stenting. In this initial work, we present CFD results in simplified geometries representing the proximal pulmonary artery and bifurcation. Methods Blood flow simulations were performed using an implementation of the finite volume method. The flow was assumed to be incompressible and governed by the Newtonian Navier-Stokes equations. Physiological vessel dimensions and boundary conditions were used in the models. Local velocities and wall shear stress values were evaluated numerically. Results and Discussion Blood flow in the pulmonary bifurcation is strongly dependent on the local geometrical characteristics and haemodynamic conditions. An increase in the flow separation is observed when the angle of the bifurcation increases. In addition, the geometry has a significant effect on the velocities and shear stresses developed on the vessel wall. Future work will involve anatomically-correct reconstructions from CT and MRI image data of adult congenital heart patients that have or are about to undergo pulmonary valve replacement. Numerical studies of these models will provide an insight into the underlying flow mechanisms of more complex 3D patient-specific geometries.

ORCID iDs

Boumpouli, Maria, Danton, Mark, Gourlay, Terence and Kazakidi, Asimina ORCID logoORCID: https://orcid.org/0000-0001-7124-4123;
  • Item type:Conference or Workshop Item(Other)
    ID code:65638
    Dates:
    Date
    Event
    22 July 2018
    Published
    8 February 2018
    Accepted
    31 December 2017
    Submitted
    Subjects:Medicine
    Department:Faculty of Engineering > Biomedical Engineering
    Depositing user: Pure Administrator
    Date deposited:03 Oct 2018 10:23
    Last modified:11 Nov 2024 16:55
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/65638
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