A numerical approach for the assessment of obesity-induced vascular changes in children
Kazakidi, Asimina (2018) A numerical approach for the assessment of obesity-induced vascular changes in children. In: 8th World Congress of Biomechanics, 2018-07-08 - 2018-07-12, Convention Centre Dublin.
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Abstract
Obesity in children and adolescents has taken epidemic proportions in recent years and has become one of the major challenges of the 21st century. Primarily a dietary disease, obesity is believed to accelerate the initiation and progression of endothelial dysfunction [1], one of the early biological markers for atherosclerotic lesions that underlie most cardiovascular diseases. Several markers have been proposed to help the clinical assessment of endothelial damage in high-risk paediatric patients. In obese children, arterial changes can painlessly be evaluated with measurements of the aortic and carotid intima-media thickness (IMT) and flowmediated dilatation (FMD) of the brachial, radial and femoral arteries [2]. Pulse wave analysis is additionally utilised to assess arterial stiffness, distensibility and compliance. This study observes childhood obesity under the magnifying lens of blood flow mechanics associated with obesity-induced vascular changes. The scope is to develop a safe and high-fidelity multi-scale computational tool for prognostic markers and predictive personalised care of obesity-related cardiovascular diseases, and transfer it into the paediatric reality. The current presentation will discuss a computational model of an arterial conduit during FDM.
ORCID iDs
Kazakidi, Asimina ORCID: https://orcid.org/0000-0001-7124-4123;-
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Item type: Conference or Workshop Item(Other) ID code: 65583 Dates: DateEvent8 July 2018Published13 March 2018Accepted4 January 2018SubmittedSubjects: Technology > Engineering (General). Civil engineering (General) > Bioengineering Department: Faculty of Engineering > Biomedical Engineering Depositing user: Pure Administrator Date deposited: 01 Oct 2018 13:23 Last modified: 27 Sep 2024 00:28 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/65583