Hepatoprotective, antihyperglycemic and antidiabetic effects of Dendrophthoe pentandra leaf extract in rats

Hasan, Mahadi and Ali, Mohammad Tuhin and Khan, Rifat and Palit, Parag and Islam, Aminul and Seidel, Veronique and Akter, Rabeya and Nahar, Laizuman (2018) Hepatoprotective, antihyperglycemic and antidiabetic effects of Dendrophthoe pentandra leaf extract in rats. Clinical Phytoscience, 4 (16).

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    Abstract

    Background: Dendrophthoe pentandra (L.) Miq. is a mistletoe species used in traditional medicine. Juice of leaves is used in wound healing, skin infection and cancer; whereas the whole plant is used to treat hypertension and cough. D. pentandra leaf extract has attracted interest due to its pharmacological properties including antioxidant, cytotoxicity and anti-inflammatory effects. In this study, we have investigated the hepatopotective, antihyperglycemic and antidiabetic potential of D. pentandra leaf extracts in rats. Methods: D. pentandra leaf methanolic extract (DPLME) at a fixed dose of 400 mg/kg body weight was evaluated for its effects on fasting glucose levels of rats. DPLME at the same dose was also used to determine the antidiabetic potential in alloxan-induced diabetic rats and the hepatopotective effects on Paracetamol (PCM) intoxicated rats. Results: Oral administration of DPLME exhibited a significantly notable oral glucose tolerance in rats. Single doses of the DPLME displayed very significant antidiabetic activity which was comparable to the activity of the standard antihyperglycemic agent Metformin (MET). DPLME also offered significant hepatoprotection to PCM-intoxicated rats at levels commensurable to the standard hepatoprotective drug Silymarin (SIL). Conclusions: The results of the present study showed that the DPLME possesses hepatopotective, antihyperglycemic and antidiabetic activity. All these results could be due to the presence of the bioactive components in the extract and this warrant further investigation on the nature of the phytochemical(s) responsible for the observed effects.