Oxidative Heck desymmetrisation of 2,2-disubstituted cyclopentene-1,3-diones

Walker, S. E. and Lamb, C. J. C. and Beattie, N. A. and Nikodemiak, P. and Lee, Ai -Lan (2015) Oxidative Heck desymmetrisation of 2,2-disubstituted cyclopentene-1,3-diones. Chemical Communications, 51. pp. 4089-4092. ISSN 1359-7345 (https://doi.org/10.1039/C5CC00407A)

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Oxidative Heck couplings have been successfully developed for 2,2-disubstituted cyclopentene-1,3-diones. The direct coupling onto the 2,2-disubstituted cyclopentene-1,3-dione core provides a novel expedient way of enantioselectively desymmetrising all-carbon quaternary centres.