Picture of UK Houses of Parliament

Leading national thinking on politics, government & public policy through Open Access research

Strathprints makes available scholarly Open Access content by researchers in the School of Government & Public Policy, based within the Faculty of Humanities & Social Sciences.

Research here is 1st in Scotland for research intensity and spans a wide range of domains. The Department of Politics demonstrates expertise in understanding parties, elections and public opinion, with additional emphases on political economy, institutions and international relations. This international angle is reflected in the European Policies Research Centre (EPRC) which conducts comparative research on public policy. Meanwhile, the Centre for Energy Policy provides independent expertise on energy, working across multidisciplinary groups to shape policy for a low carbon economy.

Explore the Open Access research of the School of Government & Public Policy. Or explore all of Strathclyde's Open Access research...

In-line monitoring of particle size and shape from image-based measurements

Cardona, J. and Ferreira, C. and McGinty, J. and Hamilton, A. and Agimelen, O.S. and Cleary, A. and Chen, Y.C. and Sefcik, J. and Michie, C. and Atkinson, R. and Andonovic, I. and Tachtatzis, C. (2017) In-line monitoring of particle size and shape from image-based measurements. In: ISIC20, 2017-09-03 - 2017-09-06, University College Dublin.

Text (Cardona-etal-ISIC-2017-In-line-monitoring-of-particle-size-and-shape-from-image-based)
Accepted Author Manuscript

Download (300kB)| Preview


    Within the pharmaceutical industry, particle size and shape distributions are crucial properties of crystalline particles produced in crystallisation processes. They determine the success or otherwise of processes such as granulation, suspension treatment and drying, all involved in the manufacture of the final pharmaceutical product. Some properties of the final pharmaceutical product such as dissolution behaviour are also influenced by the particle size and shape distribution of its ingredients. Therefore, crystallisation processes need to be controlled in order to produce particles with the desired attributes (size and shape). This in turn requires an accurate characterisation of the particle attributes during the crystallisation processes. Traditionally, particle size and shape are determined by means of off-line measurements. However, these techniques only provide information on the final state of the process and involve intermediate processing steps (e.g. sampling, dissolution, drying) that can alter the properties of the particles before the measurement. In recent years, a range of in-line techniques has been developed to obtain in-situ and real-time information on the state of the process in a non-disruptive manner.