Particle size distributions and performance of preferential crystallization of L-asparagine·H2O with tailor-made additives

Kongsamai, Peetikamol and Flood, Chalongsri and ter Horst, Joop H. and Flood, Adrian E. (2018) Particle size distributions and performance of preferential crystallization of L-asparagine·H2O with tailor-made additives. Chemical Engineering and Technology. ISSN 0930-7516

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    Abstract

    Preferential crystallization (PC) is a process to separate enantiomers. The efficiency of seeded, isothermal PC was enhanced using tailor-made additives to inhibit the crystallization of the counter-enantiomer. The inhibition of D-asparagine (D-Asn) monohydrate using D-glutamic acid (D-Glu) and D-aspartic acid (D-Asp) as additives in PC was investigated by comparing the purity, yield, and particle size distribution after PC of L-Asn·H2O from DL-Asn·H2O. The amount of pure L-Asn·H2O solid product that can be produced before crystallization of the counter-enantiomer is higher when using the additives D-Asp and D-Glu. However, the crystal size of L-Asn·H2O increases faster in PC without additives than in PC with additives. This means that the additives inhibit not only the crystallization of D-Asn·H2O but also the crystal growth of L-Asn·H2O.

    Author(s):Kongsamai, Peetikamol, Flood, Chalongsri, ter Horst, Joop H. ORCID: https://orcid.org/0000-0003-0118-2160 and Flood, Adrian E.
    Item type:Article
    ID code:64387
    Notes:This is the pre-peer reviewed version of the following article: Kongsamai, P, Flood, C, ter Horst, JH & Flood, AE 2018, 'Particle size distributions and performance of preferential crystallization of L-asparagine·H2O with tailor-made additives' Chemical Engineering and Technology, which has been published in final form at https://doi.org/10.1002/ceat.201700668. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
    Keywords:additives, amino acids, chiral separation, inhibition of crystallization, preferential crystallization, Chemistry, Chemistry(all), Chemical Engineering(all), Industrial and Manufacturing Engineering
    Subjects:Science > Chemistry
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:11 Jun 2018 10:41
    Last modified:27 Aug 2019 01:41
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/64387
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