Particle size distributions and performance of preferential crystallization of L-asparagine·H2O with tailor-made additives
Kongsamai, Peetikamol and Flood, Chalongsri and ter Horst, Joop H. and Flood, Adrian E. (2018) Particle size distributions and performance of preferential crystallization of L-asparagine·H2O with tailor-made additives. Chemical Engineering and Technology. ISSN 0930-7516
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Abstract
Preferential crystallization (PC) is a process to separate enantiomers. The efficiency of seeded, isothermal PC was enhanced using tailor-made additives to inhibit the crystallization of the counter-enantiomer. The inhibition of D-asparagine (D-Asn) monohydrate using D-glutamic acid (D-Glu) and D-aspartic acid (D-Asp) as additives in PC was investigated by comparing the purity, yield, and particle size distribution after PC of L-Asn·H2O from DL-Asn·H2O. The amount of pure L-Asn·H2O solid product that can be produced before crystallization of the counter-enantiomer is higher when using the additives D-Asp and D-Glu. However, the crystal size of L-Asn·H2O increases faster in PC without additives than in PC with additives. This means that the additives inhibit not only the crystallization of D-Asn·H2O but also the crystal growth of L-Asn·H2O.
Creators(s): |
Kongsamai, Peetikamol, Flood, Chalongsri, ter Horst, Joop H. ![]() | Item type: | Article |
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ID code: | 64387 |
Notes: | This is the pre-peer reviewed version of the following article: Kongsamai, P, Flood, C, ter Horst, JH & Flood, AE 2018, 'Particle size distributions and performance of preferential crystallization of L-asparagine·H2O with tailor-made additives' Chemical Engineering and Technology, which has been published in final form at https://doi.org/10.1002/ceat.201700668. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
Keywords: | additives, amino acids, chiral separation, inhibition of crystallization, preferential crystallization, Chemistry, Chemistry(all), Chemical Engineering(all), Industrial and Manufacturing Engineering |
Subjects: | Science > Chemistry |
Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
Depositing user: | Pure Administrator |
Date deposited: | 11 Jun 2018 10:41 |
Last modified: | 21 Jan 2021 10:03 |
Related URLs: | |
URI: | https://strathprints.strath.ac.uk/id/eprint/64387 |
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