A review of disintegration mechanisms and measurement techniques
Markl, Daniel and Zeitler, J. Axel (2017) A review of disintegration mechanisms and measurement techniques. Pharmaceutical Research, 34 (5). pp. 890-917. ISSN 0724-8741 (https://doi.org/10.1007/s11095-017-2129-z)
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Abstract
Pharmaceutical solid dosage forms (tablets or capsules) are the predominant form to administer active pharmaceutical ingredients (APIs) to the patient. Tablets are typically powder compacts consisting of several different excipients in addition to the API. Excipients are added to a formulation in order to achieve the desired fill weight of a dosage form, to improve the processability or to affect the drug release behaviour in the body. These complex porous systems undergo different mechanisms when they come in contact with physiological fluids. The performance of a drug is primarily influenced by the disintegration and dissolution behaviour of the powder compact. The disintegration process is specifically critical for immediate-release dosage forms. Its mechanisms and the factors impacting disintegration are discussed and methods used to study the disintegration in-situ are presented. This review further summarises mathematical models used to simulate disintegration phenomena and to predict drug release kinetics.
ORCID iDs
Markl, Daniel ORCID: https://orcid.org/0000-0003-0411-733X and Zeitler, J. Axel;-
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Item type: Article ID code: 64118 Dates: DateEvent1 May 2017Published1 March 2017Published Online16 February 2017AcceptedSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 22 May 2018 15:22 Last modified: 16 Dec 2024 15:21 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/64118