Characterisation of pore structures of pharmaceutical tablets : a review
Markl, Daniel and Strobel, Alexa and Schlossnikl, Rüdiger and Bøtker, Johan and Bawuah, Prince and Ridgway, Cathy and Rantanen, Jukka and Rades, Thomas and Gane, Patrick and Peiponen, Kai-Erik and Zeitler, J. Axel (2018) Characterisation of pore structures of pharmaceutical tablets : a review. International Journal of Pharmaceutics, 538 (1-2). pp. 188-214. ISSN 1873-3476 (https://doi.org/10.1016/j.ijpharm.2018.01.017)
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Abstract
Traditionally, the development of a new solid dosage form is formulation-driven and less focus is put on the design of a specific microstructure for the drug delivery system. However, the compaction process particularly impacts the microstructure, or more precisely, the pore architecture in a pharmaceutical tablet. Besides the formulation, the pore structure is a major contributor to the overall performance of oral solid dosage forms as it directly affects the liquid uptake rate, which is the very first step of the dissolution process. In future, additive manufacturing is a potential game changer to design the inner structures and realise a tailor-made pore structure. In pharmaceutical development the pore structure is most commonly only described by the total porosity of the tablet matrix. Yet it is of great importance to consider other parameters to fully resolve the interplay between microstructure and dosage form performance. Specifically, tortuosity, connectivity, as well as pore shape, size and orientation all impact the flow paths and play an important role in describing the fluid flow in a pharmaceutical tablet. This review presents the key properties of the pore structures in solid dosage forms and it discusses how to measure these properties. In particular, the principles, advantages and limitations of helium pycnometry, mercury porosimetry, terahertz time-domain spectroscopy, nuclear magnetic resonance and X-ray computed microtomography are discussed.
ORCID iDs
Markl, Daniel ORCID: https://orcid.org/0000-0003-0411-733X, Strobel, Alexa, Schlossnikl, Rüdiger, Bøtker, Johan, Bawuah, Prince, Ridgway, Cathy, Rantanen, Jukka, Rades, Thomas, Gane, Patrick, Peiponen, Kai-Erik and Zeitler, J. Axel;-
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Item type: Article ID code: 63841 Dates: DateEvent1 March 2018Published16 January 2018Published Online5 January 2018AcceptedSubjects: Medicine > Pharmacy and materia medica Department: UNSPECIFIED Depositing user: Pure Administrator Date deposited: 24 Apr 2018 14:27 Last modified: 23 Nov 2024 01:11 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/63841