Comparative analysis of the toxicity of gold nanoparticles in zebrafish

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Patibandla, Srinath and Zhang, Yinan and Tohari, Ali Mohammad and Gu, Peng and Reilly, James and Chen, Yu and Shu, Xinhua (2018) Comparative analysis of the toxicity of gold nanoparticles in zebrafish. Journal of Applied Toxicology. ISSN 0260-437X (https://doi.org/10.1002/jat.3628)

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Abstract

The use of nanoparticles - particles that range in size from 1 to 100 nanometres - has become increasingly prevalent in recent years, bringing with it a variety of potential toxic effects. Zebrafish embryos were exposed during the 3-day post-fertilisation period to gold nanospheres (GSSs), gold nanorods (GNRs), gold nanorods coated with polystyrene-sulfate (PSS-GNRs), and gold nanorods coated with both polystyrene-sulfate and polyallamine hydrochloride (PAH/PSS-GNRs). All nanorods were stabilised with cetyltrimethylammonium bromide (CTAB). GNSs were the least toxic of the nanoparticles studied, with exposure resulting in no significant changes in mortality, hatching or heart rate. Exposure to GNRs and PSS-GNRs resulted in significant increases in mortality and significant decreases in hatching and heart rate. Treatment with GNRs caused significant changes in the expression of a variety of oxidative stress genes. The toxic effects of GNRs were ameliorated by coating them with polystyrene-sulfate and, to a more marked extent, with a double coating of polystyrene-sulfate and polyallamine hydrochloride.

  • Item type:Article
    ID code:63720
    Dates:
    Date
    Event
    15 April 2018
    Published
    15 April 2018
    Published Online
    9 March 2018
    Accepted
    Subjects:Science > Physics
    Department:Faculty of Science > Physics
    Depositing user: Pure Administrator
    Date deposited:16 Apr 2018 09:12
    Last modified:11 Nov 2024 11:58
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/63720
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