Solution co-crystallisation and its applications

Leyssens, Tom and ter Horst, Joop H.; Tiekink, Edward R T and Zukerman-Schpector, Julio, eds. (2017) Solution co-crystallisation and its applications. In: Multi-Component Crystals. Walter de Gruyter GmbH, Berlin, pp. 205-236. ISBN 9783110463651 (

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Even though the term co-crystal remains topic of debate, general consensus evolves towards defining co-crystals as crystalline compounds constructed of 2 or more neutral components which are, in their pure form, solid at room temperature and under atmospheric pressure. In most cases this definition clearly distinguishes co-crystals from salts or solvates. For solvates one of the components in its pure form, the solvent, is a liquid. A co-crystal is different from a salt since it is constructed from two distinct neutral components without any charge transfer taking place between components. Co-crystals can therefore be formed of components that lack ionizable functional groups.