Associations of vigorous-intensity physical activity with biomarkers in youth

Moore, Justin B. and Beets, Michael W. and Brazendalea, Keith and Blair, Steven N. and Pate, Russell R. and Andersen, Lars B. and Anderssen, Sigmund A. and Grøntved, Anders and Hallal, Pedro C. and Kordas, Katarzyna and Kriemler, Susi and Reilly, John J. and Sardinha, Luis B. (2017) Associations of vigorous-intensity physical activity with biomarkers in youth. Medicine and Science in Sports and Exercise, 49 (7). 1366–1374. ISSN 1530-0315 (

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Introduction: Physical activity (PA) conveys known cardiometabolic benefits to youth, but the contribution of vigorous-intensity PA (VPA) to these benefits is unknown. Therefore, we sought to determine, a) the associations between VPA and cardiometabolic biomarkers independent of moderate-intensity PA (MPA) and time sedentary, and b) the accelerometer cutpoint that best represents the threshold for health-promoting VPA in youth.Methods: Data from the International Children's Accelerometry Database (ICAD) were analyzed in 2015. The relationship between cardiometabolic biomarkers and 4 categories of VPA estimated via 3 sets of cutpoints were examined using isotemporal substitution quantile regression modeling at the 10th, 25th, 50th, 75th, and 90th percentile of the distribution of each biomarker, separately. Age, sex, accelerometer wear time, sedentary time, and MPA were controlled for while allowing substitution for light-intensity PA. Data from 11,588 youth (4-18yrs) from 11 ICAD studies (collected 1998-2009) were analyzed.Results: Only 32 of 360 significant associations were observed. Significant, negative relationships were observed for VPA with waist circumference and insulin. Replacing light intensity PA with VPA (corresponding to at the 25th to 90th percentiles of VPA) was associated with a .67 (-1.33, -0.01; P = .048) to 7.30cm (-11.01, -3.58; P < .001) lower waist circumference using Evenson and ICAD cutpoints (i.e., higher CPM). VPA levels were associated with 12.60 (-21.28, -3.92; P = .004) to 27.03 pmol/l (-45.03, -9.03; P = .003) lower insulin levels at the 75th to 90th percentiles using Evenson and ICAD cutpoints when substituted for light PA.Conclusions: Substituting light PA with VPA was inversely associated with waist circumference and insulin. However, VPA was inconsistently related to the remaining biomarkers after controlling for time sedentary and MPA.