Objective, continuous measurement of sedentary behaviour and glucose in people with type 2 diabetes

McMillan, Kathryn Anne and Kirk, Alison and Hewitt, Allan and MacRury, Sandra (2017) Objective, continuous measurement of sedentary behaviour and glucose in people with type 2 diabetes. In: Diabetes UK Professional Conference 2017, 2017-03-08 - 2017-03-10, Manchester Central.

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Aims: To explore the relationship between daily levels of sitting/lying and glucose in people with Type 2 diabetes (T2D) using objective and continuous measurements. Methods: Ten participants with T2D managed with diet, Metformin or DPP4 inhibitors were recruited (mean age 63.5±9.4 years & BMI 30.8±6.9 kg/cm2). Participants completed a demographic questionnaire and wore an activPAL accelerometer and FreeStyle Libre continuous glucose monitor for 3-14 days whilst documenting sleep, food and medication. Average proportion of time spent sitting/lying, and daily mean glucose during the waking day were calculated. A multiple linear regression was calculated to explore the relationship between time spent sitting/lying, age, BMI, and daily mean glucose. Results: On average, participants spent 67.5% of their day sitting/lying and mean daily glucose was 7.7 (±1.8) mmol/l. Regression analysis suggested a significant effect (F(3,105) = 16.52, p <0.01) for sitting/lying time, age and BMI on daily mean glucose (R2 = 0.30). Participants’ predicted daily mean glucose is equal to -12.23 + 5.14(sitting/lying) + 0.16(age) + 0.21(BMI), with daily mean glucose increasing by 5.14mmol/l for each percent of daily sitting/lying, 0.16mmol/l for each increasing year of age and 0.21mmol/l for each increasing BMI unit. Conclusions: Average sitting/lying time was higher than has previously been reported and percentage sitting/lying time, age and BMI were identified as significant predictors of higher daily mean glucose in people with T2D. Results suggest that increased sedentariness is associated with increased daily mean glucose in those with T2D.