Highlights of natural compounds in prostate cancer drug discovery

Salvador, Jorge A. R. and Moreira, Vânia M.; Spiess, Philippe E., ed. (2011) Highlights of natural compounds in prostate cancer drug discovery. In: Prostate Cancer - From Bench to Bedside. INTECHopen, London, pp. 463-492. ISBN 978-953-308-80-6

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    Abstract

    The remarkable impact of natural products (NPs) in the quest for new agents and new directions in medicinal discovery is well established. The exploration of Nature as a source of novel active agents that may serve as leads and scaffolds for drugs targeting a myriad of diseases and the use of synthetic organic chemistry to modify them have been a driving force for drug discovery. Worldwide, prostate cancer (PC) is the second leading cause of death after lung cancer on both USA and Australia, and the third after lung and colo-rectal cancers in Europe.