Picture of mobile phone running fintech app

Fintech: Open Access research exploring new frontiers in financial technology

Strathprints makes available Open Access scholarly outputs by the Department of Accounting & Finance at Strathclyde. Particular research specialisms include financial risk management and investment strategies.

The Department also hosts the Centre for Financial Regulation and Innovation (CeFRI), demonstrating research expertise in fintech and capital markets. It also aims to provide a strategic link between academia, policy-makers, regulators and other financial industry participants.

Explore all Strathclyde Open Access research...

Control of malaria by bio-therapeutics and drug delivery systems

Al Qaraghuli, Mohammed M. and Obeid, Mohammad A. and Aldulaimi, Omar and Ferro, Valerie A. (2017) Control of malaria by bio-therapeutics and drug delivery systems. Journal of Medical Microbiology & Diagnosis. (In Press)

[img]
Preview
Text (Al-Qaraghuli-etal-MMD-2017-Control-of-malaria-by-bio-therapeutics-and-drug-delivery-systems)
Al_Qaraghuli_etal_MMD_2017_Control_of_malaria_by_bio_therapeutics_and_drug_delivery_systems.pdf
Accepted Author Manuscript
License: Creative Commons Attribution 4.0 logo

Download (272kB) | Preview

Abstract

Malaria is an ubiquitous disease that can affect more than 40% of the world’s population who live with some risk of contracting this disease. The World Health Organization (WHO) has recently highlighted the high spread of this disease in Sub-Saharan Africa. Despite the considerable fall in mortality rate over the past decade, the development of resistance against main treatment strategies still exists. This problem has provoked scientific efforts to develop various treatment strategies including use of vaccines, drug delivery systems, and biotherapeutics approaches. A vaccination strategy is being implemented to trigger direct clearance of the causative parasites from the human host. However, the complex life-cycle of Plasmodium parasites with continuous antigenic mutations has partly hindered this approach so far. The application of different types of drug delivery systems for the delivery of anti-malarial drugs is also being considered in order to improve the efficacy, pharmacokinetics, tolerability, and reduce toxicity of existing anti-malarial drugs. A third approach has emerged from the high success of antibodies to treat complex diseases like cancer and autoimmune diseases. Various antibody engineering methods and formats have been proposed to tackle the notable sophisticated lifecycle of malaria. Within the malaria research field, the characteristics of these diverse treatment strategies, individually, are broadly acknowledged. This review article considers the current status of these approaches and the future outlook.