Delivering natural products and biotherapeutics to improve drug efficacy

Obeid, Mohammad A. and Al Qaraghuli, Mohammed M. and Alsaadi, Manal and Alzahrani, Abdullah R. and Niwasabutra, Kanidta and Ferro, Valerie A. (2017) Delivering natural products and biotherapeutics to improve drug efficacy. Therapeutic Delivery, 8 (11). 947–956. ISSN 2041-5990 (

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Due to the increasing problem of drug resistance, new and improved medicines are required. Natural products and biotherapeutics offer a vast resource for new drugs; however, challenges, including the cost and time taken for traditional drug discovery processes and the subsequent lack of investment from the pharmaceutical industry, are associated with these areas. New techniques are producing compounds with appropriate activity at a faster rate. While the formulation of these combined with drug-delivery systems offers a promising approach for expanding the drug developments available to modern medicine. Here, various classes of drug-delivery systems are described and the advantages they bring to small molecule and biotherapeutic targeting are highlighted. This is an attractive approach to the pharmaceutical industry and the rising trend in research in this area is examined in brief.